Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We therefore conducted this meta-analysis to assess the clinicopathological impact of the expression of androgen receptor (AR) and estrogen receptors (ERs) in bladder cancer.
|
28362839 |
2017 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then assessed the effects of androgen on β-catenin in AR-positive and AR-negative bladder cancer cell lines.
|
23447569 |
2013 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We indicate that AR plays an essential role in bladder cancer progression in male patients.
|
31119584 |
2019 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We discuss work demonstrating AR expression in bladder cancer and its role in promoting formation and progression of tumors.
|
26229034 |
2015 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer.
|
30864720 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that androgens may not only function via the classic nAR to increase the nAR-positive BCa cell invasion, they may also function via this newly identified mAR-SLC39A9 to increase the nAR-negative/mAR-positive BCa cell invasion.
|
31506605 |
2020 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these results provide the first detailed mechanism of how the AR can differentially alter PCa and BCa metastasis; thus, targeting the newly identified AR-miR-525-5p-SLPI axis may help suppress metastasis.
|
31843555 |
2020 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to delineate the role of AR signaling in BCa and to determine whether the combination of AR inhibitor, Enzalutamide (Enz), and Cisplatin (Cis) efficiently inhibit the growth of BCa cells.
|
31006613 |
2019 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thiazolyl blue cell viability assay, flow cytometry, scratch wound-healing assay, transwell invasion assay, real-time polymerase chain reaction, and reporter gene assay were performed in AR-positive (e.g., UMUC3, TCCSUP, and 647V-AR) and AR-negative (e.g., UMUC3-AR-short hairpin RNA [shRNA], TCCSUP-AR-shRNA, 647V) bladder cancer lines treated with dihydrotestosterone and each AR antagonist.
|
27330033 |
2016 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that AR activity inversely correlates with radiosensitivity in bladder cancer.
|
29720561 |
2018 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of androgen receptor in cell growth and drug sensitivity was also evaluated in vitro and in vivo in several bladder cancer cell lines.
|
22608749 |
2012 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study investigated the functional role of androgen-associated androgen receptor (AR) mediated-eRNA MARC1 (eMARC1) in BCa progression.
|
29964053 |
2018 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed.
|
28869948 |
2017 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies suggest that the androgen receptor (AR) might play important roles in influencing bladder cancer progression, yet its clinical application remains unclear.
|
26264279 |
2015 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Preclinical models have demonstrated that androgen receptor modulation can influence bladder carcinogenesis with an inverse association observed between serum androgen levels and bladder cancer (BC) incidence.
|
29731413 |
2018 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that enzalutamide may have the potential to treat patients with advanced gemcitabine-resistant bladder cancer with increased AR expression.
|
27909718 |
2017 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings implicate the involvement of both androgens and the AR in bladder cancer.
|
17406000 |
2007 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
NF-κB activators and inhibitors also significantly induced and reduced, respectively, cell proliferation/migration/invasion of AR-positive bladder cancer lines, but not AR-knockdown or AR-negative lines, and their growth in xenograft-bearing mice.
|
29592878 |
2018 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that suppression of AR expression decreased the production of TGF-β, inhibiting EMT and bladder cancer cell growth in vitro and in vivo, implying that its use might be a potential therapeutic target for the treatment of bladder cancer.
|
24329492 |
2014 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, androgen-mediated androgen receptor signals have been shown to correlate with the promotion of tumor development and progression, which may clearly explain some sex-specific differences in bladder cancer.
|
28241422 |
2017 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using 'androgen receptor or AR', 'testosterone', 'bladder cancer' and 'non-muscle invasive bladder cancer or NMIBC' as keywords.
|
31803932 |
2019 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, ELK1 appears to require activated AR to regulate bladder cancer cell proliferation, but not cell migration.
|
26342199 |
2015 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, crosstalk between AR and EGFR pathways in bladder cancer remains uncharacterized.
|
22922989 |
2012 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given that the androgen receptor (AR) has been discussed as a possible factor in the development and progression of bladder cancer, we investigated the predictive value of AR in stage pT1 NMIBC.
|
28342317 |
2017 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, in vivo mouse models of xenografted bladder cancer T24 cells with CD4(+) T cells confirmed in vitro coculture studies and concluded that infiltrating CD4(+) T cells can promote bladder cancer metastasis via modulation of the IL1→AR→HIF1α→VEGFa signaling.
|
27196763 |
2016 |